Peptide therapy is a newly emerging science that helps to achieve different types of body transitions, both internal and external. Simply put, peptides are small proteins formed of short chains of amino acids that the body uses as hormones and signaling molecules for biological pathways.
These proteins are in charge of the way your body functions. Your weight loss, your sexual capability, including your digestion activities. They are also somewhat managed by these proteins. Peptide therapy helps the body impersonate the functions of naturally occurring peptides to imitate certain abilities on focused areas.
Although peptide therapy is fairly new, as of 2015, there were over 60 US FDA-approved peptide prescription medications, 140 peptide prescriptions being considered in clinical trials and 500 in pre-clinical development. In recent years, the use of peptides in health care has gained much popularity. Peptide treatment is generally considered risk-free and can be employed to produce very targeted effects. Several peptides have been approved by the FDA permitting them to get utilized for medical trials and use.
Leading the Way
in Peptide Therapy
Since peptides vary in design and number, effects vary as well. Peptide therapy has been used to treat age-related conditions, osteoporosis, obesity, inflammatory disease and even neuropathy issues. This type of therapy treatment provides a much less invasive alternative to medicines and procedures we have become all too familiar and complacent with. In addition, since the body is already familiarized to these peptides, they are synthesized, naturally causing less strain. Think about how your body processes naturally occurring peptides, like insulin and endorphins. Peptide therapy is not introducing the body to anything unfamiliar, which is what makes this form of therapy so scientifically reliable. Peptide therapies can be generated utilizing chemical processes, or produced inside genetically modified cells. Various peptide therapies are offered by injection or cream. Since peptide therapy is based off of how the body naturally operates, there have not been many recognized negative reactions linked with the administration concerning this type of therapy.
Who Benefits From Peptide Therapy Treatment?
Since peptides can treat very specific conditions in the body, there is a very wide range of benefits. Peptides can be used to improve overall wellness in the body as well as limit the effects of aging in the body. Some of the conditions it can improve are: inflammation, weight management, improving your libido, stimulating growth hormones, helping with anxiety and depression, joint and muscle repair, improving mental clarity and focus, insomnia, and even preventing skin cancer by increasing the melanin in your skin.
Patients with Lyme disease, chronic inflammation, autoimmune disease and other chronic degenerative conditions may benefit from utilizing peptides in their treatment plan.
Peptide therapy encompasses different drugs with diverse effects, extending from immune modulation and tissue repair to weight loss and weight training.
What Kinds of Peptides Are There?
The most common peptide used in peptide therapy is Thymosin alpha-1. Thymosin alpha-1, or TA1 is a peptide that is naturally produced in the thymus gland and lymphoid tissue. It basically helps the body’s ability to protect against foreign invaders that can harm the body. It has been studied extensively for its ability enhance the immune system for cancer patients undergoing chemotherapy.
Thymosin alpha-1 (T α 1) is a peptide, or small protein, consisting of 28 amino acids. T α 1 is produced naturally by the thymus gland. The thymus is located behind the sternum and between the lungs, and is where immune cells known as T cells mature and are released, prompted to do so by the T α 1 peptide. T cell production and action within the body is vital to adaptive immunity—the mode by which immune cells are able to recognize and eradicate foreign invaders.
T α 1 Helps Support Important Immune Cells
T α 1 has been found to have a profound effect on the immune system, and is used to treat hepatitis B and C, and has been studied extensively for its ability to support an immune system that has been suppressed by chemotherapy in cancer patients.
Specifically, T α 1 has been shown to enhance the function of certain immune cells called T and dendritic cells. This is very important to anyone with a depressed immune system or suffering from an infection, as these white blood cells play pivotal roles in the body’s defense process. T cells, for example, come in two forms: killer and helper T cells.
Killer T cells are responsible for hunting down and destroying our body’s own cells that are cancerous or infected with bacteria or viruses. Helper cells work with the other cells of the immune system to orchestrate and carry out appropriate immune responses.
Dendritic cells are just as valuable to our body’s defense system. These cells gather important information about infection or the presence of cancerous cells, and communicate with the T cells, who then act appropriately to eradicate the unhealthy cells and stop the infection or cancer growth.
T α 1 itself has been shown to exhibit antibacterial and anti-fungal properties, suppress tumor growth, increase vaccine effectiveness, and protect against oxidative damage.
Infection and T α 1
Studies have shown that individuals fighting infection have a lower amount of circulating T α 1 and suppressed helper T cell numbers compared to healthy individuals. This is problematic, as optimal immune function is vital to recovery from infection. Supplementation with T α 1 has the potential for great therapeutic benefit for patients suffering from infection or autoimmune disease.
In addition to its use in the treatment of Hepatitis, AIDS, and cancer, T α 1 has shown great promise in the treatment of Lyme disease. This is unsurprising when one considers the large role the immune system plays in combating the disease.
T α 1 assists the immune system in the location and eradication of the Lyme bacteria and infected cells, while helping to prevent oxidative damage, thereby decreasing inflammation and enabling better quality of life throughout treatment.
Administration and Side Effects
The T α 1 peptide can be administered via subcutaneous injection. T α 1 has been found to be very safe, and there have not been any documented side effects associated with its administration. It is approved in more than 37 countries for the treatment of hepatitis B, hepatitis C, and as an adjunct to chemotherapy and various vaccines.
Growth Hormone Secretagogues (GHSs)
This class of peptides includes a number of therapeutics that boost growth hormone (hGH) secretion. Each peptide varies just a little as far as structure and mechanism of action.
For this reason, a certain peptide may be selected depending on the patient’s health status and desired end result. GHSs include: CJC 1295, GHRP 2, GHRP 6, Hexarelin, and Ipamorelin.
Types of Peptides
Learn more about the various types of Peptides - click on their names to learn more about each of them and the benefits they provide.
Thymosin Beta 4
Thymosin beta 4 (Tβ4) is the predominant form of thymosin in our bodies. It has been found in high concentrations in wound tissue and certain blood cells involved in clotting, signifying its important role in the healing process. In fact, recent studies have revealed that the first gene to be unregulated after an injury is the Tβ4 gene.
As the body begins the recovery process, Tβ4 aids in the creation of new vessels in the injured area, which carry blood, nutrients, and reparative substances to the site. Tβ4 also has anti-inflammatory properties, and works to decrease the amount of inflammatory substances, called cytokines. Inflammation plays a large role in many of the symptoms associated with a large number of conditions (i.e., Lyme disease, CFS, FM, autoimmune diseases, infections, etc.), making the potential impact of Tβ4 quite extensive.
Supplementing with Tβ4
The discovery of the role of Tβ4 in the process of immune regulation has lead to its use as a valuable therapeutic agent. Tβ4 has been used in the treatment of HIV, AIDS, Influenza, colds, and various infections. It has been utilized in the management of various inflammatory conditions, as well as part of treatment following heart attack due to its cardio and neuroprotective effects.
Tβ4 has been used at our clinic with a great deal of success in patients suffering from Lyme disease or other infectious and/or inflammatory conditions. Tβ4 is very well tolerated and has not been found to cause any significant side effects. It can be taken on its own or in conjunction with an existing therapy, making it a versatile and valuable drug.
Cerebrolysin—also known as FPE 1070—is a synthetic nootropic drug. Nootropic drugs are substances that enhance cognitive functions such as memory, creativity, and motivation in otherwise healthy individuals. This peptide is extremely small, allowing it to penetrate the blood-brain barrier and act directly on the neurons of the central nervous system. Cerebrolysin has been found to improve the metabolic activity of brain tissue, shield neurons from harmful substances, and stimulate the peripheral and central nervous systems. In addition to its utility as a nootropic substance, the drug has potential as part of a treatment plan addressing Alzheimer’s disease, stroke, and moderate to severe head injury.
Hexarelin is a peptide that is derived from GHRP 6, but has been optimized to enhance its metabolic stability. Like the other GHSs, hexarelin increases hGH production, resulting in increased muscle mass, bone density, skin elasticity, and decreased body fat. Unlike the other GHRPs, however, hexarelin does not lead to a substantial increase in ghrelin and therefore does not cause the same appetite stimulation. This peptide has been further promoted for its cardioprotective and regenerative action as well. Hexarelin would be an ideal choice for those looking to benefit from increased growth hormone without appetite stimulation.
CJC 1295 is a growth hormone releasing hormone (GHRH) analogue. It is a molecule that stimulates the anterior pituitary to release hGH. However, unlike GHRH, which has a half-life of only minutes after IV administration, CJC 1295 is able to remain active in the body for extended periods due to its ability to bind to a protein in the blood known as albumin and avoid degradation by various enzymes. CJC 1295 increases an important growth factor, IGF-1, in addition to hGH, leading to fat loss, lean muscle growth, and enhanced sleep.
Growth hormone releasing peptide (GHRP) 2 is a type of peptide therapeutic that mimics the effects of ghrelin, the “hunger hormone”. Ghrelin is a hormone that helps regulate appetite as well as energy distribution and rate of use or metabolism. In the 1980’s, ghrelin was discovered to be the body’s natural ligand (or binding molecule) of the GHRP receptor in the anterior pituitary. This was a significant discovery, as it highlighted the role of ghrelin in hGH secretion and growth regulation.
Similar to GHRP 2, this peptide is a more potent releaser of growth hormone, also acting on the ghrelin receptors of the anterior pituitary. Also like GHRP 2, GHRP 6 leads to increased growth hormone production, increased lead body mass, and decreased adiposity. Due to the peptide’s ghrelin-like properties, administration can lead to increased appetite.
Melanotan II is an analogue of alpha melanocyte stimulating hormone, the hormone responsible for pigmentation in skin and hair. This peptide has been shown not only to increase skin pigmentation, resulting in a substantially tanner skin tone, but also to stimulate fat loss and increase libido. Its aphrodisiac effects were so substantial that it was the basis for the development of another peptide designed exclusively to address erectile and sexual dysfunction—Bremelanotide PT 141.
Ipamorelin stands out among other GHSs due to its enhanced specificity. This peptide generates similar increases in growth hormone secretion, but without the appetite stimulation and increase in cortisol, acetylcholine, prolactin, and aldosterone seen with other peptides in its class. This peptide has been found to be very well-tolerated.
Bremelanotide PT 141
Bremelanotide PT 141 was developed from Melanotan II, targeting its aphrodisiac effects. This peptide has been shown to have a substantial effect on libido, generating sexual arousal in both men and women within minutes of administration. It has been shown to be effective in treating erectile dysfunction, even in men who have not responded to other ED treatments, such as Viagra. This peptide is also able to cross the blood-brain-barrier, bypassing the vascular system and acting at the level of the central nervous system. This property gives Bremelanotide an advantage over traditional ED drugs, which can decrease blood pressure to dangerous levels. This peptide can be administered as a nasal spray, making its use convenient and discreet.
SARMs S4 & S22
SARMs are selective androgen receptor modulators. Androgens are naturally occurring hormones—such as testosterone—that regulate the development and maintenance of male sex characteristics. SARMs provide the benefits of anabolic steroids (i.e., increased muscle mass/strength, fat loss, increased bone density, increased libido) without the quantity and/or severity of unwanted effects. SARMs are not toxic to the liver, separating them from most oral steroids and making them an attractive treatment option to those looking to benefit from anabolic steroid drugs.
MGF stands for mechano growth factor—a peptide derived from insulin-like growth factor-1 (IGF-1), which plays a large role in childhood development and continues to have anabolic effects throughout adulthood. MGF has the ability to encourage repair and growth of wasted tissue through the activation of muscle stem cells, thereby increasing the synthesis of proteins necessary for tissue growth. This peptide is ideal of anyone suffering from muscle loss, either due to old age or a particular condition (i.e., HIV, cancer, etc.)
Follastatin 344 & 315
These peptides are inhibitors of a protein called myostatin. Myostatin is secreted by muscle cells and acts to essentially block the development of new muscle fibers and, thus, the development of lean muscle mass. In fact, individuals who have mutations in the gene coding for this protein have significantly more muscle mass and enhanced strength. The administration of follastatin peptides can generate enhanced muscle mass and strength, and has been found especially useful in patients suffering from muscle-wasting diseases or who have difficulty gaining muscle.
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